Flavi_glycoprot

• PFAM accession number: PF00869
• Interpro abstract (IPR011998):

  Flaviviruses and alphaviruses are arthropod-borne, enveloped RNA viruses that cause infections in vertebrate hosts [ (PUBMED:15378043) ]. These viruses have two envelope glycoproteins (also known as 'spike' glycoproteins), one that undergoes proteolytic cleavage to prime the virus (glycoproteins M and P62 in flaviviruses and alphaviruses, respectively), and the other to mediate receptor binding and fusion (glycoproteins E and E1 in flaviviruses and alphaviruses, respectively). Glycoprotein E/E1 is comprised of three domains: domain I (dimerisation domain) is a beta-barrel, domain II (central domain) is an elongated beta-stranded and alpha-helical domain, and domain III (immunoglobulin-like domain) is an IgC-like beta-sandwich. This entry represents the intertwined central and dimerisation domains found in flaviviral glycoprotein E [ (PUBMED:12759475) ] and alphaviral glycoprotein E1 [ (PUBMED:11301009) ] proteins.

• GO function: protein dimerization activity (GO:0046983)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Flavi_glycoprot