SMART: Pfam domain FmdE

FmdE

PFAM accession number:	PF02663
Interpro abstract (IPR003814):	This entry represents a domain found in subunit E of formylmethanofuran dehydrogenase (FmdE). It appears to be related to the Tubulin/FtsZ 2-layer sandwich domain. Formylmethanofuran dehydrogenases ( EC 1.2.7.12 ), found in methanogenic archaea, are molybdenum or tungsten iron-sulphur proteins containing a pterin dinucleotide cofactor. Formylmethanofuran dehydrogenase catalyses the reversible reduction of CO ₂ and methanofuran via N-carboxymethanofuran (carbamate) to N-formylmethanofuran, the first and second steps in methanogenesis from CO ₂ [ (PUBMED:8575452) ]. There are two isoenzymes of formylmethanofuran dehydrogenase: a tungsten-containing isoenzyme (Fwd) and a molybdenum-containing isoenzyme (Fmd). The tungsten isoenzyme is constitutively transcribed, whereas transcription of the molybdenum operon is induced by molybdate [ (PUBMED:9818358) ].

PFAM accession number:

PF02663

Interpro abstract (IPR003814):

This entry represents a domain found in subunit E of formylmethanofuran dehydrogenase (FmdE). It appears to be related to the Tubulin/FtsZ 2-layer sandwich domain.

Formylmethanofuran dehydrogenases ( EC 1.2.7.12 ), found in methanogenic archaea, are molybdenum or tungsten iron-sulphur proteins containing a pterin dinucleotide cofactor. Formylmethanofuran dehydrogenase catalyses the reversible reduction of CO ₂ and methanofuran via N-carboxymethanofuran (carbamate) to N-formylmethanofuran, the first and second steps in methanogenesis from CO ₂ [ (PUBMED:8575452) ]. There are two isoenzymes of formylmethanofuran dehydrogenase: a tungsten-containing isoenzyme (Fwd) and a molybdenum-containing isoenzyme (Fmd). The tungsten isoenzyme is constitutively transcribed, whereas transcription of the molybdenum operon is induced by molybdate [ (PUBMED:9818358) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry FmdE