SMART: Pfam domain GTP

GTP_cyclohydro2

PFAM accession number:	PF00925
Interpro abstract (IPR032677):	This domain is found in members of the GTP cyclohydrolase II RibA-like superfamily. Members in this family includes GTP cyclohydrolase II, riboflavin biosynthesis protein RibBA and 3,4-dihydroxy-2-butanone 4-phosphate synthase. GTP cyclohydrolase II is absent in higher eukaryotes, which makes it a potential antimicrobial drug target. The structure of GTP cyclohydrolase II reveals both a different protein fold to eukaryotic GTP cyclohydrolase I and distinctive molecular recognition determinants for GTP [ (PUBMED:16115872) ]. GTP cyclohydrolase II (also known as ribA) catalyses the first committed step in the biosynthesis of riboflavin (vitamin b2). The enzyme converts GTP and water to formate, 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)- pyrimidine and pyrophosphate, and requires magnesium as a cofactor. In numerous bacteria and in plants, GTP cyclohydrolase II occurs in the C-terminal of a bifunctional enzyme known as ribBA, which also comprises an N-terminal 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP_synthase, also known as RibB) ( IPR000422 ). RibB catalyses the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [ (PUBMED:10940330) ].

PFAM accession number:

PF00925

Interpro abstract (IPR032677):

This domain is found in members of the GTP cyclohydrolase II RibA-like superfamily. Members in this family includes GTP cyclohydrolase II, riboflavin biosynthesis protein RibBA and 3,4-dihydroxy-2-butanone 4-phosphate synthase.

GTP cyclohydrolase II is absent in higher eukaryotes, which makes it a potential antimicrobial drug target. The structure of GTP cyclohydrolase II reveals both a different protein fold to eukaryotic GTP cyclohydrolase I and distinctive molecular recognition determinants for GTP [ (PUBMED:16115872) ].

GTP cyclohydrolase II (also known as ribA) catalyses the first committed step in the biosynthesis of riboflavin (vitamin b2). The enzyme converts GTP and water to formate, 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)- pyrimidine and pyrophosphate, and requires magnesium as a cofactor. In numerous bacteria and in plants, GTP cyclohydrolase II occurs in the C-terminal of a bifunctional enzyme known as ribBA, which also comprises an N-terminal 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP_synthase, also known as RibB) ( IPR000422 ). RibB catalyses the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [ (PUBMED:10940330) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry GTP_cyclohydro2