The domain within your query sequence starts at position 169 and ends at position 258; the E-value for the Geminin domain shown below is 4.8e-20.



PFAM accession number:PF07412
Interpro abstract (IPR022786):

Geminin and multicilin belong to the geminin family.

Geminin inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex, and is degraded during the mitotic phase of the cell cycle. It has been proposed that geminin inhibits DNA replication during S, G2, and M phases and that geminin destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle [ (PUBMED:9635433) ]. The family also includes multicilin, which is required for multiciliate cell differentiation in diverse tissues [ (PUBMED:22231168) ]. It acts by promoting transcription of genes required for multiciliate cell formation, including FoxJ1 and genes mediating centriole assembly.

Multicilin (also known as Idas) is required for multiciliate cell differentiation in diverse tissues [ (PUBMED:22231168) ]. Multicilin coordinately promotes cell cycle exit, centriole assembly, and FoxJ1 expression [ (PUBMED:24064211) ]. It can form heterodimer with Geminin [ (PUBMED:24064211) ].

GO process:regulation of DNA replication (GO:0006275)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Geminin