The domain within your query sequence starts at position 225 and ends at position 323; the E-value for the Glyco_hydro_2 domain shown below is 6.4e-12.

TYIDDITVITNVEQDIGLVTYWISVQGSEHFQLEVQLLDEGGKVVAHGTGNQGQLQVPSA
NLWWPYLMHEHPAYMYSLEVKVTTTESVTDYYTLPIGIR

Glyco_hydro_2

Glyco_hydro_2
PFAM accession number:PF00703
Interpro abstract (IPR006102):

O-Glycosyl hydrolases ( EC 3.2.1. ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ (PUBMED:7624375) (PUBMED:8535779) ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.

Glycoside hydrolase family 2 comprises enzymes with several known activities: beta-galactosidase ( EC 3.2.1.23 ); beta-mannosidase ( EC 3.2.1.25 ); beta-glucuronidase ( EC 3.2.1.31 ).

These enzymes contain a conserved glutamic acid residue which has been shown [ (PUBMED:1350782) ], in Escherichia coli lacZ ( P00722 ), to be the general acid/base catalyst in the active site of the enzyme.

This entry describes the immunoglobulin-like beta-sandwich domain [ (PUBMED:8008071) ].

GO process:carbohydrate metabolic process (GO:0005975)
GO function:hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Glyco_hydro_2