The domain within your query sequence starts at position 20 and ends at position 388; the E-value for the Glyco_hydro_30 domain shown below is 1e-186.

AQPCIPKSFGYSSVVCVCNASYCDSLDPVTLPALGTFSRYESTRRGRRMELSVGAIQANR
TGTGLLLTLQPEKKFQKVKGFGGAMTDATALNILALSPPTQKLLLRSYFSTNGIEYNIIR
VPMASCDFSIRVYTYADTPNDFQLSNFSLPEEDTKLKIPLIHQALKMSSRPISLFASPWT
SPTWLKTNGRVNGKGSLKGQPGDIFHQTWANYFVKFLDAYAKYGLRFWAVTAENEPTAGL
FTGYPFQCLGFTPEHQRDFISRDLGPALANSSHDVKLLMLDDQRLLLPRWAEVVLSDPEA
AKYVHGIAVHWYMDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGM
QYSHSIITG

Glyco_hydro_30

 Glyco_hydro_30
PFAM accession number:PF02055
Interpro abstract (IPR033453):

Glycoside hydrolase family 30 comprises enzymes with only one known activity; glucosylceramidase ( EC 3.2.1.45 ).

Family 30 encompasses the mammalian glucosylceramidases. Human acid beta-glucosidase (D-glucosyl-N-acylsphingosine glucohydrolase), cleaves the glucosidic bonds of glucosylceramide and synthetic beta-glucosides [ (PUBMED:3456607) ]. Any one of over 50 different mutations in the gene of glucocerebrosidase have been found to affect activity of this hydrolase, producing variants of Gaucher disease, the most prevalent lysosomal storage disease [ (PUBMED:3456607) (PUBMED:9316290) ].

This entry represents a TIM-barrel domain found in the glycosyl hydrolase family 30 members.

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Glyco_hydro_30