GspH

• PFAM accession number: PF12019
• Interpro abstract (IPR022346):

  GspH is involved in bacterial type II export systems [ (PUBMED:18241884) ]. Like all pilins, GspH has an N terminus alpha helix [ (PUBMED:18241884) ]. This helix is followed by nine beta strands forming two beta sheets, one of five antiparallel strands and one of four antiparallel strands [ (PUBMED:18241884) ]. GspH is a minor pseudopilin; it is expressed much less than other pseudopilins in the type II secretion pilus (major pilins) [ (PUBMED:18241884) ]. The function and localisation of minor pseudo-pilins are still to be fully unraveled [ (PUBMED:18241884) ]. It has been suggested that some minor pseudopilins may assemble either into the base or the tip of pili, or both. They function as initiators or regulators of pilus biogenesis and dynamics, and/or as adaptors between various pseudopilin component and other members of the T2SS [ (PUBMED:18241884) ].

• GO process: protein secretion by the type II secretion system (GO:0015628)
• GO component: type II protein secretion system complex (GO:0015627)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry GspH