The domain within your query sequence starts at position 47 and ends at position 130; the E-value for the Guanylin domain shown below is 2.4e-33.
DSLYHGFQVQLESVKKLNELEEKEMSNPQPRRSGLLPAVCHNPALPLDLQPVCASQEAAS TFKALRTIATDECELCINVACTGC
Guanylin |
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| PFAM accession number: | PF02058 |
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| Interpro abstract (IPR000879): | This entry represents the guanylin family. Its members include guanylate cyclase activator 2A and 2B. They are endogenous activators of intestinal guanylate cyclases. Guanylin, a 15-amino-acid peptide, is an endogenous ligand of the intestinal receptor guanylate cyclase-C, known as STaR [ (PUBMED:7713512) (PUBMED:1409606) ]. Upon receptor binding, guanylin increases the intracellular concentration of cGMP, it induces chloride secretion and decreases intestinal fluid absorption, ultimately causing diarrhoea [ (PUBMED:1346555) ]. The peptide stimulates the enzyme through the same receptor binding region as the heat-stable enterotoxins [ (PUBMED:1409606) ]. |
| GO component: | extracellular region (GO:0005576) |
| GO function: | guanylate cyclase activator activity (GO:0030250) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry Guanylin