HTH_IclR

• PFAM accession number: PF09339
• Interpro abstract (IPR005471):

  The many bacterial transcription regulation proteins which bind DNA through a 'helix-turn-helix' motif can be classified into subfamilies on the basis of sequence similarities. One of these subfamilies, called 'iclR', groups several proteins including:

  • gylR, a possible activator protein for the gylABX glycerol operon in Streptomyces.
  • iclR, the repressor of the acetate operon (also known as glyoxylate bypass operon) in Escherichia coli and Salmonella typhimurium.

  These proteins have a Helix-Turn-Helix motif at the N terminus that is similar to that of other DNA-binding proteins [ (PUBMED:1840643) ].

• GO process: regulation of transcription, DNA-templated (GO:0006355)
• GO function: DNA binding (GO:0003677)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry HTH_IclR