The domain within your query sequence starts at position 45 and ends at position 265; the E-value for the HVSL domain shown below is 6.3e-70.



PFAM accession number:PF09749
Interpro abstract (IPR027521):

Proteins in this family are phosphodiesterases responsible for trimming the poly (U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA [ (PUBMED:22899009) ].

In Saccharomyces cerevisiae, Usb1 is an essential protein that localises to the nucleus and mitochondria [ (PUBMED:14562095) ]. Usb1 overexpression can compensate for specific respiratory defects of an oxa1 yeast mutant [ (PUBMED:22027258) ].

In humans, Usb1 is localised to the nucleus and is involved in the 2',3'-cyclic phosphate formation at the 3' end of U6 snRNA [ (PUBMED:22899009) ]. The human protein has been shown to degrade both oligo(U) and oligo(A) tails at the 3' end of U6 snRNA [ (PUBMED:23190533) ]. Its crystal structure has been solved and shows a globular alpha-beta-type architecture [ (PUBMED:23190533) ]. Mutation in Usb1 is linked to poikiloderma with neutropenia (PN), a genodermatosis characterised by poikiloderma, pachyonychia and chronic neutropenia [ (PUBMED:20004881) (PUBMED:20503306) ].

GO process:U6 snRNA 3'-end processing (GO:0034477)
GO function:nuclease activity (GO:0004518)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry HVSL