Herpes_glycop_D

• PFAM accession number: PF01537
• Interpro abstract (IPR002896):

  Herpesviruses are dsDNA viruses with no RNA stage. This entry represents a conserved domain found in several Herpes viruses glycoproteins, including:

  • Glycoprotein-D (gD or gIV), which is common to Human herpesvirus 1 (HHV-1) and Human herpesvirus 2 (HHV-2), as well as Equid herpesvirus 1, Bovine herpesvirus 1 and Meleagrid herpesvirus 1 (MeHV-1). Glycoprotein-D has been found on the viral envelope and the plasma membrane of infected cells. gD immunisation can produce an immune response to bovine herpes virus (BHV-1). This response is stronger than that of the other major glycoproteins gB (gI) and gC (gIII) in BHV-1 [ (PUBMED:7530392) (PUBMED:7612933) (PUBMED:16292345) (PUBMED:11511370) ].
  • Glycoprotein G (gG), which is one of the seven external glycoproteins of Human herpesvirus 1 (HHV-1) and Human herpesvirus 2 (HHV-2) [ (PUBMED:3027242) ]. In the HHV-2 virus-infected cell, gG-2 is cleaved into a secreted amino-terminal portion (sgG-2) and a carboxy-terminal portion. The latter protein is further O-glycosylated, generating the cell membrane-associated mature gG-2 (mgG-2). The mgG-2 protein has widely been used as a prototype antigen for detection of type-specific antibodies against HHV-2 [ (PUBMED:12904375) ].
  • Glycoprotein GX (gX), which was initially identified in Suid herpesvirus 1 (Pseudorabies virus).

• GO component: integral component of membrane (GO:0016021)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Herpes_glycop_D