SMART: Pfam domain Hint

Hint

PFAM accession number:	PF01079
Interpro abstract (IPR001767):	Hedgehog proteins are a family of secreted signal molecules required for embryonic cell differentiation. They are synthesised as inactive precursors with an N-terminal signalling domain linked to a C-terminal autoprocessing domain. The three-dimensional structure of the autolytic domain of the hedgehog protein of shows similarity with the beta-strand core of intein splicing domains. It has hence been termed the hint (Hedgehog/Intein) domain [ (PUBMED:9489693) ]. This entry represents the Hint module in the Hedgehog proteins. It does not include any Inteins, which also possess the Hint domain.
GO process:	protein autoprocessing (GO:0016540)

PFAM accession number:

PF01079

Interpro abstract (IPR001767):

Hedgehog proteins are a family of secreted signal molecules required for embryonic cell differentiation. They are synthesised as inactive precursors with an N-terminal signalling domain linked to a C-terminal autoprocessing domain. The three-dimensional structure of the autolytic domain of the hedgehog protein of shows similarity with the beta-strand core of intein splicing domains. It has hence been termed the hint (Hedgehog/Intein) domain [ (PUBMED:9489693) ].

This entry represents the Hint module in the Hedgehog proteins. It does not include any Inteins, which also possess the Hint domain.

GO process:

protein autoprocessing (GO:0016540)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Hint