SMART: Pfam domain Hint

Hint_2

PFAM accession number:	PF13403
Interpro abstract (IPR028992):	This entry represents a domain found in the pretoxin HINT domain protein and the C-terminal of protein hedgehog. Hedgehog proteins are a family of secreted signal molecules required for embryonic cell differentiation. They are synthesised as inactive precursors with an N-terminal signalling domain linked to a C-terminal autoprocessing domain. The three-dimensional structure of the autoprocessing domain shows similarity with the beta-strand core of intein splicing domains. It has hence been termed the Hedgehog/Intein (Hint) domain [ (PUBMED:9489693) ].

PFAM accession number:

PF13403

Interpro abstract (IPR028992):

This entry represents a domain found in the pretoxin HINT domain protein and the C-terminal of protein hedgehog.

Hedgehog proteins are a family of secreted signal molecules required for embryonic cell differentiation. They are synthesised as inactive precursors with an N-terminal signalling domain linked to a C-terminal autoprocessing domain. The three-dimensional structure of the autoprocessing domain shows similarity with the beta-strand core of intein splicing domains. It has hence been termed the Hedgehog/Intein (Hint) domain [ (PUBMED:9489693) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Hint_2