SMART: Pfam domain HlyD

HlyD_D23

PFAM accession number:	PF16576
Interpro abstract (IPR032317):	CusB can be divided into four different domains. The first three domains of the protein are mostly beta-strands. However, the fourth domain forms an all alpha-helical domain, which is folded into a three-helix bundle secondary structure [ (PUBMED:19695261) ]. This is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons [ (PUBMED:19695261) ].

PFAM accession number:

PF16576

Interpro abstract (IPR032317):

CusB can be divided into four different domains. The first three domains of the protein are mostly beta-strands. However, the fourth domain forms an all alpha-helical domain, which is folded into a three-helix bundle secondary structure [ (PUBMED:19695261) ].

This is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons [ (PUBMED:19695261) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry HlyD_D23