SMART: Pfam domain Inhibitor

Inhibitor_I69

PFAM accession number:	PF13734
Interpro abstract (IPR025896):	This domain family includes the protease inhibitor Spi. The domain is also found in the pro-peptides of streptopain (SpeB). SpeB is produced as a 43kDa pre-pro-protein, which is secreted via the recently described Sec secretory pathway Exportal. There is tight coupling between this inhibitor and its associated protease: the gene for the inhibitor Spi is located directly downstream from the gene for the streptococcal cysteine protease SpeB, and the sequence of the inhibitor is very similar to that of the SpeB propeptide. This is an example of an inhibitor molecule that is a structural homologue of the cognate propeptide, and is genetically linked to the protease gene [ (PUBMED:16045611) (PUBMED:10681429) ].

PFAM accession number:

PF13734

Interpro abstract (IPR025896):

This domain family includes the protease inhibitor Spi. The domain is also found in the pro-peptides of streptopain (SpeB). SpeB is produced as a 43kDa pre-pro-protein, which is secreted via the recently described Sec secretory pathway Exportal. There is tight coupling between this inhibitor and its associated protease: the gene for the inhibitor Spi is located directly downstream from the gene for the streptococcal cysteine protease SpeB, and the sequence of the inhibitor is very similar to that of the SpeB propeptide. This is an example of an inhibitor molecule that is a structural homologue of the cognate propeptide, and is genetically linked to the protease gene [ (PUBMED:16045611) (PUBMED:10681429) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Inhibitor_I69