The domain within your query sequence starts at position 284 and ends at position 351; the E-value for the Inhibitor_Mig-6 domain shown below is 2.9e-30.
SPPRVPPREPLSPQGSRTPSPLVPPGSSPLPHRLSSSPGKTMPTTQSFASDPKYATPQVI QAPGPRAG
Inhibitor_Mig-6 |
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PFAM accession number: | PF11555 |
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Interpro abstract (IPR021619): | When the kinase domain of EGFR binds to segment one of Mitogen induced gene 6 (Mig-6), EGFR becomes inactive due to the conformation it adopts which is Src/CDK like. The binding of the two proteins prevents EGFR acting as a cyclin-like activator for other kinase domains [ (PUBMED:18046415) ].The structure of Mig-6(1) consists of alpha helices-G and -H with a polar surface and hydrophobic residues for interactions with EGFR. A critical step for the activation of EGFR is the formation of an asymmetric dimer involving the kinase domains of the protein. Since Mig-6 binds to the kinase domain it blocks this process and EGFR becomes inactive [ (PUBMED:18046415) ]. |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry Inhibitor_Mig-6