SMART: Pfam domain Keratin_2

The domain within your query sequence starts at position 501 and ends at position 633; the E-value for the Keratin_2_tail domain shown below is 7.6e-29.

MSGECTPNVSVSVSTSHTSMSGSSSRGGGSGGGRYGGGGSYGGGSGGGSYGGSSGGGGSG
GSYGGGSGGGSYGGGSGGGSSGSHRGGSGGGGGSSGGSYGGSSGGGRGGSSSGGGGVKSS
GSSTVKFVSTSYS

Keratin_2_tail

PFAM accession number:	PF16210
Interpro abstract (IPR032449):	All intermediate filament proteins feature a central alpha-helical rod domain and variable nonhelical domains located at the N-terminal (head) and C-terminal (tail). The central rod domain is the main driver of self-assembly into filaments, whereas the N- and C-terminal domains are involved in post-translational modifications and interactions with other proteins [ (PUBMED:16710422) ]. Keratin 1 (KRT1) belongs to a large family of intermediate filament protein genes and is normally expressed in keratinocytes in the spinous layer of the epidermis [ (PUBMED:12711220) ]. This entry represents the C-terminal domain (tail) of type II keratin KRT1.

PFAM accession number:

PF16210

Interpro abstract (IPR032449):

All intermediate filament proteins feature a central alpha-helical rod domain and variable nonhelical domains located at the N-terminal (head) and C-terminal (tail). The central rod domain is the main driver of self-assembly into filaments, whereas the N- and C-terminal domains are involved in post-translational modifications and interactions with other proteins [ (PUBMED:16710422) ]. Keratin 1 (KRT1) belongs to a large family of intermediate filament protein genes and is normally expressed in keratinocytes in the spinous layer of the epidermis [ (PUBMED:12711220) ]. This entry represents the C-terminal domain (tail) of type II keratin KRT1.

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Keratin_2_tail