The domain within your query sequence starts at position 1 and ends at position 88; the E-value for the LAMTOR5 domain shown below is 2.1e-37.
MEATLEQHLEDTMKNPSIVGVLCTDSQGLNLGCRGTLSDEHAGVISVLAQQAARLTSDPT DIPVVCLESDNGNIMIQKHDGITVAVHK
LAMTOR5 |
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| PFAM accession number: | PF16672 |
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| Interpro abstract (IPR024135): | Hepatitis B X-interacting protein (HBXIP, also known as LAMTOR5) was originally recognised for its association with the X protein of hepatitis B virus (HBV) and ability to down-regulate HBV replication [ (PUBMED:9499022) ]. When complexed to the anti-apoptotic protein survivin, HBXIP interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerised APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway [ (PUBMED:12773388) ]. HBXIP is one of the Ragulator components that are required for mTORC1 activation by amino acids [ (PUBMED:22980980) ]. It is also part of the AA (amino acid) sensing machinery in human CD4+ T cells [ (PUBMED:26084023) ]. |
| GO process: | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043154), negative regulation of apoptotic process (GO:0043066) |
| GO component: | Ragulator complex (GO:0071986), cytoplasm (GO:0005737) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry LAMTOR5