LTXXQ

• PFAM accession number: PF07813
• Interpro abstract (IPR012899):

  This family summarizes bacterial proteins related to CpxP, a periplasmic protein that forms part of a two-component system which acts as a global modulator of cell-envelope stress in Gram-negative bacteria. CpxP aids in combating extracytoplasmic protein-mediated toxicity, and may also be involved in the response to alkaline pH [ (PUBMED:9473036) ]. Functioning as a dimer, it inhibits activation of the kinase CpxA, but also plays a vital role in the quality control system of P pili. It has been suggested that CpxP directly interacts with CpxA via its concave polar surface [ (PUBMED:21239493) ]. Another member of this family, Spy, is also a periplasmic protein that may be involved in the response to stress [ (PUBMED:9068658) ]. The homology between CpxP and Spy suggests similar functions. A characteristic 5-residue sequence motif LTXXQ is found repeated twice in many members of this family [ (PUBMED:20799348) ].

• GO component: periplasmic space (GO:0042597)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry LTXXQ