The domain within your query sequence starts at position 70 and ends at position 186; the E-value for the LURAP domain shown below is 3.3e-56.



PFAM accession number:PF14854
Interpro abstract (IPR039499):

This entry includes a group of leucine rich adaptor proteins, including LURAP1 (LRAP35A), LURAP1L and LRAP25. LURAP1 activates the canonical NF-kappa-B pathway, promotes proinflammatory cytokine production and promotes the antigen presenting and priming functions of dendritic cells [ (PUBMED:21048106) ].

LRAP25, also known as C184M or MMTV receptor, is a Ski (a transcriptional co-repressor) binding protein that negatively regulates tumour growth factor-beta signaling by sequestering the Smad proteins in the cytoplasm [ (PUBMED:12646588) ]. LRA25 also serves as an adaptor protein of MRCK (myotonic dystrophy kinase-related Cdc42-binding kinase) [ (PUBMED:25107909) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry LURAP