SMART: Pfam domain LsmAD

The domain within your query sequence starts at position 1 and ends at position 47; the E-value for the LsmAD domain shown below is 3.6e-11.

XSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQR

LsmAD

PFAM accession number:	PF06741
Interpro abstract (IPR009604):	This entry represents a conserved region approximately 250 residues long located on eukaryotic ataxin-2 [ (PUBMED:16115810) ]. Ataxin-2 is a protein of unknown function, within which expansion of a polyglutamine tract (due to expansion of unstable CAG repeats in the coding region of the SCA2 gene) causes spinocerebellar ataxia type 2 (SCA2), a late-onset neurodegenerative disorder [ (PUBMED:9339681) ]. The expanded polyglutamine repeat in ataxin-2 causes disruption of the normal morphology of the Golgi complex and increased incidence of cell death [ (PUBMED:12812977) ]. Ataxin-2 is predicted to consist of mostly non-globular domains [ (PUBMED:9462862) ].

PFAM accession number:

PF06741

Interpro abstract (IPR009604):

This entry represents a conserved region approximately 250 residues long located on eukaryotic ataxin-2 [ (PUBMED:16115810) ]. Ataxin-2 is a protein of unknown function, within which expansion of a polyglutamine tract (due to expansion of unstable CAG repeats in the coding region of the SCA2 gene) causes spinocerebellar ataxia type 2 (SCA2), a late-onset neurodegenerative disorder [ (PUBMED:9339681) ]. The expanded polyglutamine repeat in ataxin-2 causes disruption of the normal morphology of the Golgi complex and increased incidence of cell death [ (PUBMED:12812977) ]. Ataxin-2 is predicted to consist of mostly non-globular domains [ (PUBMED:9462862) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry LsmAD