The domain within your query sequence starts at position 447 and ends at position 616; the E-value for the MAP7 domain shown below is 1.1e-59.
GVVPKTSAGTTDPEEATRLLAEKRRLAREQREKEERERKEKEELERQKIEELARRVAEER SRREEEARRLEEEQAREKEELALRLAEEERERWEREEVERVQKQKEEEARAREEAERARQ EREKHFQKEEQERLERKKRLEEIMRRTRRTETADKKTTEQRNGDIAKGVL
MAP7 |
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PFAM accession number: | PF05672 |
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Interpro abstract (IPR008604): | MAP7 (also known as E-MAP-115 or Ensconsin) is a microtubule-stabilising protein that may play an important role in microtubule reorganisation during polarisation and differentiation of epithelial cells [ (PUBMED:11719555) ]. It may play a role in the formation of intercellular contacts [ (PUBMED:11719555) (PUBMED:9989799) ]. The MAP7 family has three other members: MAP7 domain containing proteins 1 (MAP7D1), 2 (MAP7D2) and 3 (MAP7D3) [ (PUBMED:24927501) ]. MAP7D3 has been identified as a critical regulator of microtubule stability, probably through its binding to tubulin and microtubules, as well as its regulation of histone deacetylase 6 activity [ (PUBMED:22142902) (PUBMED:24614595) ]. |
GO process: | microtubule cytoskeleton organization (GO:0000226) |
GO component: | microtubule cytoskeleton (GO:0015630) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry MAP7