The domain within your query sequence starts at position 13 and ends at position 189; the E-value for the MDFI domain shown below is 1.8e-49.



PFAM accession number:PF15316
Interpro abstract (IPR026134):

This family consists of MyoD family inhibitor (I-mfa, MDFI) and MyoD family inhibitor domain-containing protein.

I-mfa acts as a transcriptional activator or repressor. It retains nuclear Zic family proteins (ZIC1, ZIC2 and ZIC3) in the cytoplasm and consequently inhibits their transcriptional activation ability [ (PUBMED:15207726) ].

I-mfa domain-containing protein interacts with HAND1 (bHLH transcription factor), leading to sequester HAND1 into the nucleolus and prevent its activity [ (PUBMED:17891141) ]. In humans modulates the expression from both cellular and viral promoters. It down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. It also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR [ (PUBMED:10671520) (PUBMED:16260749) (PUBMED:12944466) ].

Both I-mfa and I-mfa domain-containing protein interact with the axin complex and affect axin regulation of both the Wnt and the JNK activation pathways [ (PUBMED:12192039) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry MDFI