The domain within your query sequence starts at position 251 and ends at position 503; the E-value for the MSC domain shown below is 7.3e-21.

EDNMKLLPVDCERKTDEFCQAKQKAALLELLHELYNFLAIQAGNFECGNPEKLKSKCIPV
LEAQEYIANVTSSPSSRFKAALTWILSSNKDVGIWLKGEDPSELATTVDKVVCLESARPR
MGIGCRLSRALLTAVTHVLIFFWCLAFLWGLLILLKYRWRKLEEEEQAMYEMVKKIIDVV
QDHYVDWEQDMERYPYVGILHVRDSLIPPQSRRRMKRVWDRAVEFLASNESRIQTESHRV
AGEDMLVWRWTKP

MSC

MSC
PFAM accession number:PF09402
Interpro abstract (IPR018996):

MAN1 is an integral protein of the inner nuclear membrane which binds to chromatin associated proteins and plays a role in nuclear organisation. The C-terminal nucleoplasmic region forms a DNA binding winged helix and binds to Smad [ (PUBMED:16648637) ]. This C-terminal tail is also found in S. cerevisiae and is thought to consist of three conserved helices followed by two downstream strands [ (PUBMED:15611647) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry MSC