The domain within your query sequence starts at position 257 and ends at position 511; the E-value for the MTBP_C domain shown below is 2.5e-129.
PELSPGKLQVLPFEKASECHYHGIEYCLDDQKALERDGGFSELQSRLIRYETQTTCTRDS FPVPTVLSPLPSPAVLSEPQSVPEGEALQGELRTEVSGLKRRSKDPSCLYPQKRLTRSES SDCLPSQASCNSNHHHHTGKPRKPQAERCVSGLPLPGREASKDTSKTSSGQKRAHESKSS KQMKESRSQKHTRMLKEVVKDTLKRHHITEAHESFTACSQRLFDISKFYLKDLKTSRGLF EEMKKTANNNVVQVI
MTBP_C |
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PFAM accession number: | PF14920 |
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Interpro abstract (IPR029418): | This entry represents the C-terminal domain of the MDM2-binding protein (MTBP). MDM2 is an E3 ubiquitin-protein ligase that mediates ubiquitination of p53, leading to its degradation by the proteasome [ (PUBMED:14707283) ]. MTBP inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability, and this promotes MDM2-mediated ubiquitination of p53 and its subsequent degradation [ (PUBMED:15632057) ]. Mouse MTBP also inhibits cancer cell migration by interacting with alpha-actinin-4 (ACTN4) [ (PUBMED:22370640) ]. |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry MTBP_C