SMART: Pfam domain Memo

The domain within your query sequence starts at position 9 and ends at position 293; the E-value for the Memo domain shown below is 3.7e-84.

EASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDP
SVTRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDE
DEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSS
DFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHP
IGVLLNAITELQKNGMNMSFSFLNYAQSSQCRSWQDSSVSYAAGA

Memo

PFAM accession number:	PF01875
Interpro abstract (IPR002737):	This entry is composed of Memo 1 (mediator of ErbB2-driven cell motility 1) and related proteins from eukaryotes, archaea and bacteria whose molecular function is unclear. Memo 1 is an effector of the ErbB2 receptor tyrosine kinase involved in breast carcinoma cell migration [ (PUBMED:15156151) ]. It binds to a specific ErbB2-derived phosphopeptide [ (PUBMED:18045866) ]. It regulates the localisation of the small G protein RhoA and its effector mDia1 at the plasma membrane, and thereby coordinates the organisation of the lamellipodial actin network, adhesion site formation, and MT outgrowth within the cell leading edge to sustain cell motility [ (PUBMED:18955552) ]. In yeast, the homologue is known as Mho1, and inhibits haploid invasive growth when overexpressed [ (PUBMED:22412880) ].

PFAM accession number:

PF01875

Interpro abstract (IPR002737):

This entry is composed of Memo 1 (mediator of ErbB2-driven cell motility 1) and related proteins from eukaryotes, archaea and bacteria whose molecular function is unclear.

Memo 1 is an effector of the ErbB2 receptor tyrosine kinase involved in breast carcinoma cell migration [ (PUBMED:15156151) ]. It binds to a specific ErbB2-derived phosphopeptide [ (PUBMED:18045866) ]. It regulates the localisation of the small G protein RhoA and its effector mDia1 at the plasma membrane, and thereby coordinates the organisation of the lamellipodial actin network, adhesion site formation, and MT outgrowth within the cell leading edge to sustain cell motility [ (PUBMED:18955552) ]. In yeast, the homologue is known as Mho1, and inhibits haploid invasive growth when overexpressed [ (PUBMED:22412880) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Memo