Microcin

• PFAM accession number: PF03526
• Interpro abstract (IPR003061):

  The structural and functional relationships among independently cloned segments of the plasmid ColE1 region that regulates and codes for colicin E1 (cea), immunity (imm) and the mitomycin C-induced lethality function (lys) have been analysed [ (PUBMED:3936034) ]. A model for the structure and expression of the colicin E1 operon has been proposed in which the cea and lys genes are expressed from a single inducible promoter that is controlled by the lexA repressor in response to the SOS system of Escherichia coli [ (PUBMED:3936034) ]. The imm gene lies between the cea and lys genes and is expressed by transcription in the opposite direction from a promoter located within the lys gene [ (PUBMED:3936034) ]. This arrangement indicates that the transcriptional units for all three genes overlap. It is proposed that the formation of anti-sense RNA may be an important element in the coordinate regulation of gene expression in this system [ (PUBMED:3936034) ].

  Hydropathy analysis of the imm gene products suggests that they have hydrophobic domains characteristic of membrane-associated proteins [ (PUBMED:3936034) ]. The microcin E1 immunity protein is able to protect a cell that harbours the plasmid ColE1 encoding colicin E1 against colicin E1; it is thus essential both for autonomous replication and colicin E1 immunity [ (PUBMED:384144) ].

• GO process: bacteriocin immunity (GO:0030153)
• GO function: toxic substance binding (GO:0015643)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Microcin