The domain within your query sequence starts at position 8 and ends at position 156; the E-value for the Mis12 domain shown below is 2.5e-47.
YEAQFFGFTPQTCLLRIYVAFQDHLFEVMQAVEQVILKKLEDIPNCEITPVQTRKCTEKF LCFMKGRFDNLFGKMEQLILQSILCIPPNILLPEDKCQETNPFSEEKLELLQQEIKELQE KYKVELCTEQALLAELEEQKTVKAKLRET
Mis12 |
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PFAM accession number: | PF05859 |
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Interpro abstract (IPR008685): | Kinetochores are the chromosomal sites for spindle interaction and play a vital role for chromosome segregation. Fission Saccharomyces cerevisiae kinetochore protein Mis12, is required for correct spindle morphogenesis, determining metaphase spindle length [ (PUBMED:10398680) ]. Thirty-five to sixty percent extension of metaphase spindle length takes place in Mis12 mutants [ (PUBMED:10398680) ]. It has been shown that Mis12 might genetically interact with Mal2p [ (PUBMED:12242294) ]. |
GO process: | mitotic cell cycle (GO:0000278) |
GO component: | nucleus (GO:0005634), chromosome, centromeric region (GO:0000775) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry Mis12