PFAM accession number:PF04879
Interpro abstract (IPR006963):

The molybdopterin oxidoreductase 4Fe-4S domain is found in a number of reductase/dehydrogenase families, which include the periplasmic nitrate reductase precursor and the formate dehydrogenase alpha chain [ (PUBMED:9036855) ].

The following proteins contain this domain and belong to the molybdenium (Mo) or tungsten (W) containing enzyme family, the Mo/W bis-MGD (molybdopterin-guanine-dinucleotide) oxydoreductases [ (PUBMED:2015248) (PUBMED:3062312) (PUBMED:8125918) ]:

  • Escherichia coli respiratory nitrate reductase ( EC ).
  • Escherichia coli anaerobic dimethyl sulfoxide reductase (DMSO reductase).
  • Escherichia coli biotin sulfoxide reductases (genes bisC and bisZ).
  • Methanobacterium formicicum formate dehydrogenase ( EC ).
  • Escherichia coli formate dehydrogenases -H (gene fdhF), -N (gene fdnG) and -O (gene fdoG).
  • Wolinella succinogenes polysulfide reductase chain.
  • Salmonella typhimurium thiosulfate reductase (gene phsA).
  • Escherichia coli trimethylamine-N-oxide reductase ( EC ) (gene torA) [ (PUBMED:8022286) ].
  • Nitrate reductase ( EC ) from Klebsiella pneumoniae (gene nasA), Alcaligenes eutrophus, Escherichia coli, Rhodobacter sphaeroides, Thiosphaera pantotropha (gene napA), and Synechococcus PCC 7942 (gene narB).
GO process:oxidation-reduction process (GO:0055114)
GO function:oxidoreductase activity (GO:0016491)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Molybdop_Fe4S4