MukB

• PFAM accession number: PF04310
• Interpro abstract (IPR007406):

  This is the N-terminal region of MukB. MukB is involved in the segregation and condensation of prokaryotic chromosomes. MukE ( IPR007385 ) along with MukF ( IPR005582 ) interact with MukB in vivo forming a complex, which is required for chromosome condensation and segregation in Escherichia coli [ (PUBMED:10545099) ]. The Muk complex appears to be similar to the SMC-ScpA-ScpB complex in other prokaryotes where MukB is the homologue of SMC [ (PUBMED:12065423) ]. ScpA ( IPR003768 ) and ScpB ( IPR005234 ) have little sequence similarity to MukE or MukF, though they are predicted to be structurally similar, being predominantly alpha-helical with coiled coil regions.

  The structure of the N-terminal domain consists of an antiparallel six-stranded beta sheet surrounded by one helix on one side and by five helices on the other side [ (PUBMED:10545328) ]. It contains an exposed Walker A loop in an unexpected helix-loop-helix motif. In other proteins, Walker A motifs generally adopt a P loop conformation as part of a strand-loop-helix motif embedded in a conserved topology of alternating helices and (parallel) beta strands [ (PUBMED:10545328) ].

• GO process: chromosome condensation (GO:0030261), chromosome segregation (GO:0007059)
• GO component: nucleoid (GO:0009295)
• GO function: DNA binding (GO:0003677), ATP binding (GO:0005524)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry MukB