The domain within your query sequence starts at position 148 and ends at position 317; the E-value for the NACHT domain shown below is 4.5e-40.



PFAM accession number:PF05729
Interpro abstract (IPR007111):

The NACHT domain is a 300 to 400 residue predicted nucleoside triphosphatase (NTPase) domain, which is found in animal, fungal and bacterial proteins. The NACHT domain has been named after NAIP, CIITA, HET-E and TP1. It is found in association with other domains, such as the CARD domain ( IPR001315 ), the DAPIN domain ( IPR004020 ), the HEAT repeat ( IPR004155 ), the WD repeat ( IPR001680 ), the leucine-rich repeat (LRR) or the BIR repeat ( IPR001370 ) [ (PUBMED:10782090) ].

The NACHT domain consists of seven distinct conserved motifs, including the ATP/GTPase specific P-loop, the Mg(2+)-binding site (Walker A and B motifs, respectively) and five more specific motifs. The unique features of the NACHT domain include the prevalence of 'tiny' residues (glycine, alanine or serine) directly C-terminal of the Mg(2+)-coordinating aspartate in the Walker B motif, in place of a second acidic residue prevalent in other NTPases. A second acidic residue is typically found in the NACHT-containing proteins two positions downstream. Furthermore, the distal motif VII contains a conserved pattern of polar, aromatic and hydrophobic residues that is not seen in any other NTPase family [ (PUBMED:10782090) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry NACHT