SMART: Pfam domain NTP_transf

NTP_transf_4

PFAM accession number:	PF13562
Interpro abstract (IPR023917):	The MJ_1101 protein from Methanococcus jannaschii has been characterised as the GlmU, a bifunctional enzyme (UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase) catalyzing the final two steps of UDP-GlcNAc biosynthesis [ (PUBMED:18263721) ]. Homologues of this enzyme are identified in a number of bacterial organisms. A number of these are observed in proximity to the glmS and glmM genes, and phylogenetic profiling [ (PUBMED:16930487) ] identifies the LEPBI_I0518 gene in Leptospira biflexa as a likely Glm-system candidate. There are significant structural differences between these bacterial homologues with their archaeal counterparts represented by .

PFAM accession number:

PF13562

Interpro abstract (IPR023917):

The MJ_1101 protein from Methanococcus jannaschii has been characterised as the GlmU, a bifunctional enzyme (UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase) catalyzing the final two steps of UDP-GlcNAc biosynthesis [ (PUBMED:18263721) ]. Homologues of this enzyme are identified in a number of bacterial organisms. A number of these are observed in proximity to the glmS and glmM genes, and phylogenetic profiling [ (PUBMED:16930487) ] identifies the LEPBI_I0518 gene in Leptospira biflexa as a likely Glm-system candidate. There are significant structural differences between these bacterial homologues with their archaeal counterparts represented by .

This is a PFAM domain. For full annotation and more information, please see the PFAM entry NTP_transf_4