The domain within your query sequence starts at position 22 and ends at position 198; the E-value for the NUDIX_5 domain shown below is 8.1e-85.
SLNSREYRAKSYEILLHEVPIEGQKKKRKKVLLETKLQSNSEIAQGILDYVVETTKPISP ANQGIKGKRVVLMRKFPLDGEKTGREAALFIVPSVVKDNTKYAYTPGCPIFYCLQDIMRV CSESSTHFATLTARMLIALDKWLDERHAQSHFIPALFRPSPLERIKTNVINPAYAAE
NUDIX_5 |
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PFAM accession number: | PF16705 |
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Interpro abstract (IPR032022): | This domain is found in higher eukaryotes at the N terminus of KRIT1 or Krev interaction trapped proteins. It carries three NPxY-like motifs and is found to bind the integrin cytoplasmic-associated protein 1 (ICAP1). In the absence of KRIT1, ICAP1 binds via its C-terminal PH/PTB fold domain to the integrin beta-1 cytoplasmic tail. Binding of KRIT1 to ICAP1 via this domain out-competes the binding of ICAP1 to integrin cytoplasmic tails such that ICAP1 is sequestered in the nucleus. Integrin activation is thus prevented [ (PUBMED:23317506) ]. |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry NUDIX_5