NadA

• PFAM accession number: PF02445
• Interpro abstract (IPR003473):

  Quinolinate synthetase catalyses the second step of the de novo biosynthetic pathway of pyridine nucleotide formation. In particular, quinolinate synthetase is involved in the condensation of dihydroxyacetone phosphate and iminoaspartate to form quinolinic acid [ (PUBMED:10648170) ]. This synthesis requires two enzymes, an FAD-containing "B protein" and an "A protein". B protein converts L-aspartate to iminoaspartate. The A protein, NadA, converts iminoaspartate to quinolate. NadA harbours a [4Fe-4S] cluster [ (PUBMED:18803397) ].

• GO process: NAD biosynthetic process (GO:0009435)
• GO function: quinolinate synthetase A activity (GO:0008987), 4 iron, 4 sulfur cluster binding (GO:0051539)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry NadA