SMART: Pfam domain NlpE

NlpE

PFAM accession number:	PF04170
Interpro abstract (IPR007298):	This family represents a bacterial outer membrane lipoprotein that is necessary for signalling by the Cpx pathway [ (PUBMED:11830644) ]. This pathway responds to cell envelope disturbances and increases the expression of periplasmic protein folding and degradation factors. While the molecular function of the NlpE protein is unknown, it may be involved in detecting bacterial adhesion to abiotic surfaces. NlpE from Escherichia coli and Salmonella typhi is also known to confer copper tolerance in copper-sensitive strains of E. coli, and may be involved in copper efflux and delivery of copper to copper-dependent enzymes [ (PUBMED:7635807) ].

PFAM accession number:

PF04170

Interpro abstract (IPR007298):

This family represents a bacterial outer membrane lipoprotein that is necessary for signalling by the Cpx pathway [ (PUBMED:11830644) ]. This pathway responds to cell envelope disturbances and increases the expression of periplasmic protein folding and degradation factors. While the molecular function of the NlpE protein is unknown, it may be involved in detecting bacterial adhesion to abiotic surfaces. NlpE from Escherichia coli and Salmonella typhi is also known to confer copper tolerance in copper-sensitive strains of E. coli, and may be involved in copper efflux and delivery of copper to copper-dependent enzymes [ (PUBMED:7635807) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry NlpE