SMART: Pfam domain O_Spanin

O_Spanin_T7

PFAM accession number:	PF17531
Interpro abstract (IPR020130):	The lysis of Gram-negative hosts by double-strand DNA bacteriophages requires, in addition to the actions of a holin and endolysin, a third step involving the spanin complex. This complex consists of a small outer membrane lipoprotein and an integral cytoplasmic membrane protein, designated as o-spanins and i-spanins, respectively. The spanin complex is involved in the disruption of the outer membrane. Without spanin function, lysis is blocked and progeny virions are trapped in dead spherical cells [ (PUBMED:24585055) ]. This entry represents the o-spanin subunit from T7likevirus.
GO process:	viral release from host cell (GO:0019076)

PFAM accession number:

PF17531

Interpro abstract (IPR020130):

The lysis of Gram-negative hosts by double-strand DNA bacteriophages requires, in addition to the actions of a holin and endolysin, a third step involving the spanin complex. This complex consists of a small outer membrane lipoprotein and an integral cytoplasmic membrane protein, designated as o-spanins and i-spanins, respectively. The spanin complex is involved in the disruption of the outer membrane. Without spanin function, lysis is blocked and progeny virions are trapped in dead spherical cells [ (PUBMED:24585055) ].

This entry represents the o-spanin subunit from T7likevirus.

GO process:

viral release from host cell (GO:0019076)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry O_Spanin_T7