The domain within your query sequence starts at position 20 and ends at position 164; the E-value for the Osteopontin domain shown below is 2.2e-67.
KVTDSGSSEEKKLYSLHPDPIATWLVPDPSQKQNLLAPQNAVSSEEKDDFKQETLPSNSN ESHDHMDDDDDDDDDDGDHAESEDSVDSDESDESHHSDESDETVTASTQADTFTPIVPTV DVPNGRGDSLAYGLRSKSRSFQVSD
Osteopontin |
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PFAM accession number: | PF00865 |
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Interpro abstract (IPR002038): | The major event of endochondrial ossification is the proteolytic degradation of calcified cartilage and the extracellular matrix, and their substitution with bone-specific extracellular matrix produced and organised by osteoblasts [ (PUBMED:2033080) ]. One of the most abundant products of osteoblasts is osteopontin, a glycosylated phosphoprotein with a high acidic amino acid content and one copy of the cell attachment sequence RGD [ (PUBMED:2033080) ]. It is thought that osteopontin may act as a bridge between osteoblasts and the apatite mineral of the bone [ (PUBMED:2033080) ]. Osteopontin-K is a kidney protein, similar to osteopontin and probably also involved in cell adhesion [ (PUBMED:1414488) ]. |
GO process: | cell adhesion (GO:0007155), ossification (GO:0001503) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry Osteopontin