The domain within your query sequence starts at position 93 and ends at position 237; the E-value for the PA28_beta domain shown below is 5.3e-58.



PFAM accession number:PF02252
Interpro abstract (IPR003186):

The specificity of the 20S proteasome, which degrades many intracellular proteins, is regulated by protein complexes that bind to one or both ends of the cylindrical proteasome structure. Proteasome activator 28 (PA28), also known as 11S regulator or REG, is one of these complexes. PA28 binds to the 20S proteasome and stimulates peptidase activity in and ATP-independent manner.

Three PA28 subunits that have been identified, PA28alpha, PA28beta and PA28gamma (also known as the Ki antigen), which share extensive sequence similarity, apart from a highly variable internal segment [ (PUBMED:9403698) ]. PA28alpha and PA28beta form a ring shaped hexameric structure of alternating alpha and beta subunits. The catalytic properties of PA28alpha and PA28beta-activated proteosome are similar [ (PUBMED:11147828) (PUBMED:9346951) ].

This entry represents the C-terminal domain found in the proteasome activator 28 subunits.

GO component:proteasome activator complex (GO:0008537)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry PA28_beta