The domain within your query sequence starts at position 2 and ends at position 429; the E-value for the PAG domain shown below is 1.4e-208.
GPAGSVLSSGQMQMQMVLWGSLAAVAMFFLITFLVLLCSTCDREKKPRQHSGDHENLMNV PSDKDMFSHSATSLTTDALASSEQNGVLTNGDILSEDSTLTCMQHYEEVQTSASDLLDSQ DSTGKAKCHQSRELPRIPPENAVDEILTARAADTELGPGVEGPYEVLKDSSSQENMVEDC LYETVKEIKEVADKGQGGKSKSTSALKELQGAPMEGKADFAEYASVDRNKKCRHSANAES ILGTCSDLDEESPPPVPVKLLDENANLPQEGGGQAEEQAAEGTGGHSKRFSSLSYKSREE DPTLTEEEISAMYSSVNKPGQSAHKPGPCMKGPESACHSMKGLPQRSSSSCNDLYATVKD FEKTPNSISTLPPARRPSEEPEPDYEAIQTLNREDEKVPLETNGHHVPKESDYESIGDLQ QCRDVTRL
PAG |
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PFAM accession number: | PF15347 |
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Interpro abstract (IPR032748): | PAG, or Cbp/PAG (Csk binding protein/phospho-protein associated with glycosphingolipid-enriched microdomains) is a transmembrane protein that has a negative regulatory role in T-cell activation through being an adapter for C-terminal Src kinase, Csk. This family of proteins is found in eukaryotes [ (PUBMED:10790433) (PUBMED:11684085) (PUBMED:12612075) (PUBMED:22659621) ]. |
GO process: | negative regulation of T cell activation (GO:0050868), intracellular signal transduction (GO:0035556) |
GO component: | plasma membrane (GO:0005886), membrane raft (GO:0045121) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry PAG