The domain within your query sequence starts at position 22 and ends at position 171; the E-value for the PCNP domain shown below is 4.8e-71.
GPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEDEAADLPTKPTKMSKFGFAIGSQTAR KASAISIRLGASKPKETVPTLAPKTLSVAAAFNEDEDSEPEEMPPEAKMRMKNIGRDTPT SAGPNSFNKGKHGFSDNQKLWERNIKSHLG
PCNP |
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PFAM accession number: | PF15473 |
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Interpro abstract (IPR029169): | PCNP is a PEST-containing nuclear protein that is ubiquitinated by NIRF, a Np95/ICBP90-like RING finger protein probably involved in cell cycle regulation [ (PUBMED:12176013) ]. PEST sequences, which are rich in proline (P), glutamic acid (E), serine (S) and threonine (T), are found in a number of short-lived proteins, such as transcription factors and cell cycle-associated proteins. Their function is generally controlled by proteolysis, mostly via ubiquitin-mediated degradation [ (PUBMED:14741369) ]. NIRF and PCNP may constitute a novel signaling pathway with some relation to cell proliferation. |
GO process: | protein ubiquitination (GO:0016567) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry PCNP