The domain within your query sequence starts at position 11 and ends at position 140; the E-value for the PGC7_Stella domain shown below is 2.6e-24.
NIHLPRGENADVLQPETLVKVMKKLTLNPGVKRSARRRSLRNRIAAVPVENKSEKIRREV QSAFPKRRVRTLLSVLKDPIAKMRRLVRIEQRQKRLEGNEFERDSEPFRCLCTFCHYQRW DPSENAKIGK
PGC7_Stella |
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PFAM accession number: | PF15549 |
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Interpro abstract (IPR029096): | Dppa3 (developmental pluripotency-associated protein 3), also known as Stella or PGC7, belongs to family known only in placental mammals [ (PUBMED:14654002) (PUBMED:14990856) (PUBMED:17143267) ]. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization [ (PUBMED:17143267) ]. This suggests that it might bind methylated DNA sequences directly [ (PUBMED:21507349) ]. Dppa3 also seems to be involved in the demethylation process during reprogramming of embryonic germ cell precursors [ (PUBMED:23595900) ]. Most placental mammals contain 3-6 paralogues of this family. The conserved core of Dppa3 includes a positively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion [ (PUBMED:21507349) ]. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins [ (PUBMED:21507349) ]. |
GO function: | methylated histone binding (GO:0035064) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry PGC7_Stella