PIG-S

• PFAM accession number: PF10510
• Interpro abstract (IPR019540):

  Phosphatidylinositol-glycan biosynthesis class S protein (PIG-S, also known as Gpi17 in budding yeasts) is one of several key, core components of the glycosylphosphatidylinositol (GPI) trans-amidase complex that adds GPIs to newly synthesized proteins [ (PUBMED:11598210) ]. Mammalian GPI transamidase consists of at least five components: Gaa1, Gpi8, PIG-S, PIG-T, and PIG-U, all five of which are required for its function. It is possible that Gaa1, Gpi8, PIG-S, and PIG-T form a tightly associated core that is only weakly associated with PIG-U [ (PUBMED:14660601) ].

• GO process: attachment of GPI anchor to protein (GO:0016255)
• GO component: GPI-anchor transamidase complex (GO:0042765)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry PIG-S