The domain within your query sequence starts at position 12267 and ends at position 12293; the E-value for the PPAK domain shown below is 8.9e-8.



PFAM accession number:PF02818
Interpro abstract (IPR004168):

PPAK is a repeated protein motif found in the PEVK (Pro-Glu-Val-Lys) domain of the titin protein and in a number of other proteins. Titin (EC is a giant elastic protein found in striated muscle that is a key component in the assembly and functioning of sarcomeres [(PUBMED:15507486)]. PPAK motifs (PPAK refers to the four amino acids found at the beginning of the motif) occur 60 times in human soleus titin [(PUBMED:11276084)]. PPAK motifs occur in groups of 2-12 that are separated by regions rich in glutamic acid (approximately 45%) and termed polyE segments. The charge fluctuation between the PPAK and polyE regions suggests ionic interactions between these segments and their involvement in the elastic function of titin.

This is a PFAM domain. For full annotation and more information, please see the PFAM entry PPAK