The domain within your query sequence starts at position 2 and ends at position 193; the E-value for the PUMA domain shown below is 8.5e-97.



PFAM accession number:PF15826
Interpro abstract (IPR031661):

PUMA (p53 upregulated modulator of apoptosis), also known as Bbc3 (Bcl-2-binding component 3), is a critical mediator of p53-dependent and -independent apoptosis [(PUBMED:19641508)]. PUMA transduces death signals primarily to the mitochondria. It is induced in cells after p53 activation. It binds to Bcl-2, localises to the mitochondria to induce cytochrome c release, and activates the rapid induction of apoptosis [(PUBMED:11463392)]. PUMA is capable of inhibiting all the five major anti-apoptotic Bcl-2-like proteins (Mcl-1, Bcl-2, Bcl-XL, Bcl-W and A1) [(PUBMED:19641508)]. The binding of PUMA to the inhibitory members of the Bcl-2 family via its BH3 domain results in the displacement of the proteins Bax and/or Bak, and seems to be a critical regulatory step in the induction of apoptosis [(PUBMED:23001513)].

GO process:intrinsic apoptotic signaling pathway (GO:0097193), positive regulation of release of cytochrome c from mitochondria (GO:0090200), positive regulation of apoptotic process (GO:0043065)
GO component:mitochondrion (GO:0005739)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry PUMA