PdxA

• PFAM accession number: PF04166
• Interpro abstract (IPR005255):

  This entry represents the PdxA family. PdxA is an NAD+-dependent 4-hydroxythreonine 4-phosphate dehydrogenase ( EC 1.1.1.262 ) active in pyridoxal phosphate biosynthesis [ (PUBMED:12896974) ]. PdxA2, a functional paralogue of PdxA, catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-erythronate 4-phosphate to produce dihydroxyacetone phosphate (DHAP). It can also use D-threonate 4-phosphate as substrate [ (PUBMED:27294475) (PUBMED:27402745) ]. This family also includes TphB, involved in terephthalate degradation [ (PUBMED:16517628) ].

• GO process: oxidation-reduction process (GO:0055114)
• GO function: NAD binding (GO:0051287)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry PdxA