The domain within your query sequence starts at position 251 and ends at position 701; the E-value for the Peptidase_M3 domain shown below is 1.8e-158.

VMKKCCVPETRRKMEMAFHTRCKEENTIILQQLLPLRAQVAKLLGYNTHADFVLELNTAK
STSHVATFLDDLSQKLKPLGEAEREFILSLKKKECEERGFAYDGKINAWDLHYYMTQTEE
LKYSVDQESLKEYFPIEVVTEGLLSIYQELLGLSFEQVADAHVWNKSVSLYTVKDKATGE
VLGQFYLDLYPREGKYNHAACFGLQPGCLLPDGSRMMSVAALVVNFSQPIAGRPSLLRHD
EVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDIDSLRKLSKHYR
DGHPITDELLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNASLDAASEYAKYCTEILGV
AATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFHSCFRKEGIMNPEVGMKYRNLIL
KPGGSLDGMDMLQNFLQREPNQKAFLMSRGL

Peptidase_M3

• PFAM accession number: PF01432
• Interpro abstract (IPR001567):

  This group of metallopeptidases belong to MEROPS peptidase family M3 (clan MA(E)), subfamilies M3A and M3B. The protein fold of the peptidase domain for members of this family resembles that of thermolysin, the type example for clan MA.

  The Thimet oligopeptidase family, is a large family of archaeal, bacterial and eukaryotic oligopeptidases that cleave medium sized peptides. The group contains:

  • mitochondrial intermediate peptidase ( EC 3.4.24.59 )
  • Neurolysin, mitochondrial precursor, ( EC 3.4.24.16 )
  • Thimet oligopeptidase ( EC 3.4.24.15 )
  • Dipeptidyl carboxypeptidase ( EC 3.4.15.5 )
  • Oligopeptidase A ( EC 3.4.24.70 )
  • Oligoendopeptidase F
• GO process: proteolysis (GO:0006508)
• GO function: metalloendopeptidase activity (GO:0004222)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Peptidase_M3