SMART: Pfam domain Peptidase

Peptidase_M85

PFAM accession number:	PF13678
Interpro abstract (IPR025208):	This family of bacterial metallo-peptidases is thought to compromise the inflammatory response by degrading p65, thereby down-regulating the NF-kappaB signalling pathway [ (PUBMED:21187904) ]. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52; and the heterodimeric p65-p50 complex appears to be most abundant one.

PFAM accession number:

PF13678

Interpro abstract (IPR025208):

This family of bacterial metallo-peptidases is thought to compromise the inflammatory response by degrading p65, thereby down-regulating the NF-kappaB signalling pathway [ (PUBMED:21187904) ]. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52; and the heterodimeric p65-p50 complex appears to be most abundant one.

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Peptidase_M85