Peripla_BP_4

• PFAM accession number: PF13407
• Interpro abstract (IPR025997):

  Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. Most of the bacterial ABC (ATP-binding cassette) importers are composed of one or two transmembrane permease proteins, one or two nucleotide-binding proteins and a highly specific periplasmic solute-binding protein. In Gram-negative bacteria the solute-binding proteins are dissolved in the periplasm, while in archaea and Gram-positive bacteria, their solute-binding proteins are membrane-anchored lipoproteins [ (PUBMED:8003968) (PUBMED:18310026) ].

  On the basis of sequence similarities, the vast majority of these solute-binding proteins can be grouped into eight family clusters [ (PUBMED:8336670) ], which generally correlate with the nature of the solute bound. This entry represents the family 2 [ (PUBMED:8336670) (PUBMED:6340108) ].

  Family 2 members include:

  • Autoinducer 2-binding protein LsrB from E. coli and Salmonella typhimurium [ (PUBMED:15601708) (PUBMED:11722742) ]
  • D-galactose-binding periplasmic protein
  • Autoinducer 2-binding periplasmic protein LuxP
  • D-ribose-binding periplasmic protein
  • Multiple sugar-binding periplasmic receptor ChvE

  This entry represents a domain found in a variety of bacterial periplasmic binding proteins belonging mainly to family 2.

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Peripla_BP_4