SMART: Pfam domain Phage_holin_4

Phage_holin_4_1

PFAM accession number:	PF05105
Interpro abstract (IPR006480):	Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile [ (PUBMED:11444771) ]. The 1.E.10 family is represented by Bacillus subtilis phi29 holin [ (PUBMED:8432697) (PUBMED:22436471) ]; 1.E.16 represents the Cph1 holin[ (PUBMED:9440507) ]; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis [ (PUBMED:11444771) ].

PFAM accession number:

PF05105

Interpro abstract (IPR006480):

Phage holins and lytic enzymes are both necessary for bacterial lysis and virus dissemination. This family also includes TcdE/UtxA involved in toxin secretion in Clostridium difficile [ (PUBMED:11444771) ]. The 1.E.10 family is represented by Bacillus subtilis phi29 holin [ (PUBMED:8432697) (PUBMED:22436471) ]; 1.E.16 represents the Cph1 holin[ (PUBMED:9440507) ]; and the 1.E.19 family is represented by the Clostridium difficile TcdE holin. Toxigenic strains of C. difficile produce two large toxins (TcdA and TcdB) encoded within a pathogenicity locus. tcdE, encoded between tcdA and tcdB, encodes a 166 aa protein which causes death to E. coli when expressed, and the structure of TcdE resembles holins. TcdE acts on the bacterial membrane. Since TcdA and TcdB lack signal peptides, they may be released via TcdE either prior to or subsequent to cell lysis [ (PUBMED:11444771) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Phage_holin_4_1