PyrBI_leader

• PFAM accession number: PF08052
• Interpro abstract (IPR012602):

  This family consists of the pyrBI operon leader peptides. The expression of the pyrBI operon, which encodes the subunits of the pyrimidine biosynthetic enzyme aspartate transcarbamylase. is regulated primarily through a UTP-sensitive transcriptional attenuation control mechanism. In this mechanism, the concentration of UTP determines the extent of coupling between transcription and translation within the pyrBI leader region, hence determining the level of rho-independent transcriptional termination at an attenuator preceding the pyrB gene [ (PUBMED:7517939) ].

• GO process: pyrimidine nucleobase biosynthetic process (GO:0019856)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry PyrBI_leader